Two young kids form the Moochie Kalala Detectives Club to uncover the truth behind their grandpa's wild stories. Every Saturday, Grandpa comes over and shares a ridiculous story that twists the kids thinking about science. To uncover the real story, the kids head to Museums and Zoos and meet with real scientists to discover the truth. Episodes feature museums and scientists from Adler Planetarium, The Field Museum, John G. Shedd Aquarium, Museum of Science & Industry, Lincoln Park Zoo and Frank Lloyd Wright Trust.

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