In the twentieth film in the series, in 1950's Wyoming, middle-aged Indiana Jones and his friend Grey Cloud have obtained a sacred ceremonial pipe and end up in a snow-logged cabin. When Jones uncovers a soprano sax, he is reminded of his college days in 1920's Chicago, waiting tables at Colosimo's restaurant and becoming obsessed with Jazz music. When Colosimo was murdered, young Indy got caught up in the investigation together with his roommate Eliot Ness and young reporter Ernest Hemingway.

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